Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer
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چکیده
منابع مشابه
Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer.
BACKGROUND Genetic polymorphisms in the human UDP-glucuronosyltransferase-1A7 (UGT1A7) gene are detected and significantly correlated with sporadic colorectal carcinoma. UGT1A7, which has recently been demonstrated to glucuronidate environmental carcinogens, is now implicated as a cancer risk gene. A silent mutation at codon 11 and missense mutations at codons 129, 131, and 208 lead to the desc...
متن کاملGenotyping of the UDP-glucuronosyltransferase (UGT) 1A7 gene revisited.
Readers are encouraged to write letters to the editor concerning articles that have been published in GASTROENTEROLOGY. Letters that include original, unpublished data will not be considered. Letters should be typewritten and submitted electronically to In 2001 and in 2003, we published 2 studies reporting the role of single nucleotide polymorphisms (SNPs) of the mu-tagen detoxifying UDP glucur...
متن کاملAssociation between polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and colorectal cancer risk.
Genetic polymorphisms of uridine diphosphate-glucuronosyltransferases 1A6 (UGT1A6) and 1A7 (UGT1A7) may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interaction between polymorphisms of these repair genes and tobacco smoking in colorectal cancer (CRC). A total of 68 individuals with CRC and 112 non-cancer controls were divided into non-smoke...
متن کاملProduct inhibition of UDP-glucuronosyltransferase (UGT) enzymes by UDP obfuscates the inhibitory effects of UGT substrates.
Substrates that are specific for certain UDP-glucuronosyltransferase (UGT) isoforms are usually used as specific inhibitors to identify UGT isoforms responsible for the glucuronidation of drugs. 1-Naphthol and 4-nitrophenol are probe substrates for human UGT1A6. In the present study, we found that UGT1A1-catalyzed estradiol 3-O-glucuronide formation and UGT1A4-catalyzed imipramine N-glucuronide...
متن کاملPolymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer
BACKGROUND Polymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased susceptibility of colorectal cancer. UGT1A gene locus has been suggested to define tissue-specific glucuronidation activity. Reduced capacity of glucuronidation is correlated with the development of colorectal cancer. Therefore, we sought to explore polymorphism of UGTlA gene in h...
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ژورنال
عنوان ژورنال: Gut
سال: 2002
ISSN: 0017-5749
DOI: 10.1136/gut.50.6.851